Histamine, LDN & Lyme Dx Ė MS Therapies

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Thu Jul 2, 2009 11:19

Monday, June 29, 2009

Summary of Dr Zagons interview:

As I understand it, the primary effect of the low dose naltrexone (LDN) protocol, which is more accurately termed intermittent opiate blockade, is the temporary blocking of opiate receptors. Opiate receptors are proteins found on the surface of the bodyís cells, including immune system cells. Both endogenous (pentapeptide endorphins) and exogenous (opiate drugs) bind to and activate this receptor. As an opiate antagonist, naltrexone blocks the opiate receptor.

This causes the body to respond by producing more endorphins in an attempt to remedy the unavailability of the endorphin receptors. In addition, this stimulates the production of more endorphin receptors, which, in turn, increases the production of endorphin pentapeptides, including met-enkephalins, leu-enkephalins, and endorphins.

One of the issues LDN addresses is the low levels of endorphin receptor seen in some disease states. This presumably leads directly to low endorphin levels in the body. Low endorphin levels are associated with various autoimmune diseases and malignancies.

The endorphins make us feel better and happier and also perform the vital function of modulating the immune system and assisting with the repair cells in the body, modulating their populations. However, as Dr. Zagon explains, these processes are dependant on available nutrients. For people with chronic diseases, nutrient-poor diets could play a role. More research is needed in this area.

LDN can be taken at any time of the day, but the 6 hours or so after taking it are uncomfortable for most, so Dr Zagon recommends taking it at night. However if you cannot sleep because of the endorphin blockade, then take it at another time. There is no circadian rhythm reason associated with naltrexone. Thus, there is no physiological reason to take it at night.

Once the blockade is ended, the endorphins can do their work until the next dose. The more time they have to work the better, but early on in therapy, itís best to take LDN every 24 hours, allowing say 5 to 6 hours blockade and consequently 18 to 19 hours benefit time.

However, when you take LDN over extended periods, some Naltrexone will accumulate in the system and this can become troublesome. It can perhaps even prevent LDN from working well. It seems a blockade lasting longer than about 6 hours may stop the LDN working and can even make it work in the opposite direction. This can be remedied by skipping a day Ė even two days in extreme cases but no more than that! This will help reduce the accumulated level of naltrexone. Much research is needed here and naltrexone residual level monitoring equipment would help too.

However, it is important that the dose is at an effective level, which ranges from a lowest starting dose of 2 mg and up to 4.5 mg daily. Some people do take lower or higher doses, but they are exceptions and Iím not sure less than 2mg is effective anyhow.

The condition of the liver and its level of loading from digestive factors and other drugs will affect the rate at which naltrexone is metabolised and excreted. I personally believe that my leg circulation issues also cause me to retain naltrexone, interfereing with its absorption and metabolism.

Remember, we want naltrexone to be fully metabolised within under 6 hours so that we can experience the full effects of the approximately 18-hour blockade. Consequently, liver function is an important consideration. Severe liver damage may prevent LDN effect from working optimally. However, having a liver disease doesnít rule out LDN if your liver still works! In fact, LDN may well help the liver.

LDN primarily induces the production of met-5-enkephalin or opioid growth factor (OGF), followed by smaller amounts of beta endorphin. OGF is being used currently to treat cancer with huge effect. It attaches to the zeta receptor of tumour cells and slows their growth. It also inhibits blood vessel growth in tumours, effectively starving them of blood supply.

This activity allows the immune system to kill the cancer cells faster than they can grow. If that fails, we can simultaneously add chemotherapy agents to help the process. OGF is also the endorphin that most helps with the autoimmune diseases and it can be taken separately in place of or in addition to LDN. Similar to LDN, OGF modulates the immune system, has potent antioxidant properties, modulates inflammatory responses and much more.

In short, endorphins control all the systems that keep us alive from day to day. As we age, endorphin levels typically decline, and individuals start to manifest diseases that have been waiting for their chance such as MS , cancer and others. LDN and OGF offer us the chance to put these systems back in order (restore homeostasis) with the one catch, we need to keep taking them once we need them.

Imagine that the rate the bugs are trying to eat you has to be less than the rate these systems can fix you in order to be healthy. LDN turbo boosts your systems and OGF directly increases levels of met-5-ekephalin. I hope this explains a little about how to take LDN and OGF and why it does what it does.

I think we mostly need a change in the thinking of the ways doctors practice medicine. A change from symptom relief medicine to a bio-medicine which always seeks to restore or enhance the existing and highly evolved defence and repair systems of the body first. Only when that is insufficient should we be using the invasive techniques of modern medicine, which often introduce alien chemical pathways, toxins and often carry severe risks. I feel a bio-medicine first approach would reduce our need for these drugs too when they are needed. This is the best possible approach for the people who need them and I challenge the medical profession to agree or disagree with this in the light of what I have said here!

Written by A Barnett, Edited by Elaine Moore, approved by Dr Ian Zagon

  • Art Hansen and Dr. Zagon> GoodShape, Wed Jul 1 10:46
    I think Art Hansen did a good job finding the meat in Mary's somewhat difficult and sometimes confusing interview with Dr. Zigon on June 23rd. Here is what Art Posted on another Site: Summary of Dr... more
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