My mother was diabetic, I have hypoglycemia. I just started taking this stuff, I first noticed peripheral neuropathy when I was about 20 years old. The testimonials on the stuff is amazing for burning feet/neuropathy/eyesight. I am only on 150 mg, but I will increase...
Until recently, physicians could do little to prevent the dire complications of chronic hyperglycemia. Fortunately, this situation is changing. Exciting research indicates that a nutritional supplement called benfotiamine can block three of the four major metabolic pathways leading to tissue damage. Although it was synthesized in a Japanese laboratory nearly 50 years ago, benfotiamine is only now gaining recognition as a powerful supplement capable of preventing destructive aging effects in the hyperglycemic and alcoholic populations.
Benfotiamine is a slightly altered form of vitamin B1 (thiamine). The alteration renders the vitamin fat soluble, enabling it to access areas of the body that water-soluble thiamine cannot penetrate. This is crucial for controlling potential hyperglycemia-induced damage. Although the problems associated with hyperglycemia are myriad, they all stem from the root problem of glucose flooding into vascular cells and overwhelming their metabolic machinery.
One of the body’s proteins, an enzyme called transketolase, blocks the absorption of too much glucose. To do its work, however, transketolase, like many enzymes, requires a co-factor. In this case, it needs assistance from thiamine. Unfortunately, thiamine is water soluble, which makes it less available to cells. Experiments have shown that transketolase’s effects are only marginally boosted by the addition of thiamine to cell cultures bathed in excess glucose.63
Used for more than a decade in Germany to successfully treat nerve pain in diabetics, benfotiamine is considerably more available to the body than thiamine. A landmark study, published recently in the medical journal Nature Medicine, found that benfotiamine increases transketolase activity in cell cultures by an astounding 300%. By comparison, when added to cell cultures, thiamine raises transketolase activity a mere 20%. Benfotiamine’s robust activation of transketolase was sufficient to block three of the four major metabolic pathways leading to blood vessel damage. Additionally, benfotiamine blocked activation of the pro-inflammatory transcription factor nuclear factor-kappa beta.63
Nuclear factor-kappa beta has been implicated in inflammation, tumor formation, and macular degeneration, as well as retinal disease in diabetics.64,65 It regulates cellular proliferation and suicide. Blocking nuclear factor-kappa beta has been shown to improve the prognosis of arthritis patients.66 These findings suggest still more benefits of benfotiamine therapy. There
Last week I started on 150 mg Doctor's Best Bentofamine and I was rather surprised to notice better mobility, better eyesight, less joint pain... then yesterday I took 300 mg, and was able to hold... more
http://www.life-enhancement.com/article_template.asp?ID=1960 Endothelial Dysfunction The results showed that the HAGE meal produced substantial endothelial dysfunction lasting for as much as 6 hours. ... more
Marilyn - Since reading ur first post about benfot. i have been looking and its not easy to find. Where do u get it? I wud love to give it a try....im in a wheelchair and wud be greatful for anything ... more
I use this company because they ship to Canada using USPS which makes it much much more affordable for me. But they are a great company, I highly recommend them because I have used them for years and ... more
I have read a couple places to take a B. complex with it. B. vitamins tend to work synergistically... although I did read in one article not to take methylcobalamin with it, but I only saw that in... more
Sorry to bother u again Marilyn but u seem to have done quite a bit of research on this. I have been going over some of the info looking for interactions with other B vitamins. I take B-12 daily for... more
This stuff was done more for me than anything besides thyroid. Amazing reduction in pain/stiffness/contraction. I am taking 600 mg at the moment, but might experiment with more. Finally finally... more
other treatments and supplements? Do you feel it is a matter of getting all the nutrition we need to repair a system so everything works? For me this is the case. I continue to support my system as... more
Ignore my earlier post Marilyn about where u get it frm. Ur right about expensive. Im in Canada and i did find it at a compounding pharmacy 120 caps for $43.20. How much does it cost u to get it to... more
I am in Canada also and I cannot believe the price of this stuff up here. I answered you below, there are certain restrictions when using iherb.com. You cannot ship over 3 pounds at a time (but they... more
Glad to hear of your success. I just have a couple questions. 1) do you take the 600 mg at one time? 2) are you in a manual or motorized wheelchair? 3) can you stand at all? 4) can you turn over in... more
I've been taking it all at one time in the morning, on an empty stomach. Most of what I've read says that you can go up to 1200 mg without toxicity issues... there seems to be a lot of controversy... more
The thing that I find astounding about this, is that I take all kinds of B. vitamins, and have done so for years. I can't say that I've never noticed much benefit. I have injected every form of B12,... more
Whooo hoooo....I am so glad that this is helping you. I may even see about getting some for myself. I know that I have heard this recommended in the past by someone but just can't seem to remember... more