The results showed that the HAGE meal produced substantial endothelial dysfunction lasting for as much as 6 hours. The researchers suggested that this was due to a combination of two mechanisms: (1) a decrease in the rate of synthesis of nitric oxide (NO), a free radical that serves as the principal mediator of blood-pressure regulation; and (2) an increase in the scavenging of NO by entities such as AGEs, dicarbonyls, and reactive oxygen species.
At both the macrovascular (large-vessel) and microvascular (small-vessel) levels, benfotiamine reversed the observed endothelial dysfunction completely. The researchers attributed this to a reduction in the endogenous production of AGEs and dicarbonyls as well as to a reduction in oxidative stress. They based their conclusion in part on measurements of the levels of various compounds in the blood that serve as indicators of endothelial dysfunction and oxidative stress.
Benfotiamine Shows Anti-Inflammatory Effects
The researchers also observed that benfotiamine prevented a postprandial increase in circulating levels of methylglyoxal (MG) and carboxymethyllysine (CML), a commonly seen AGE. Finally, they observed that the HAGE meal induced a small rise in the subjects’ blood levels of CRP (C-reactive protein), a marker of systemic inflammation, and that benfotiamine prevented this effect. This finding jibes with previous reports suggesting that benfotiamine has both direct and indirect anti-inflammatory effects.
Last week I started on 150 mg Doctor's Best Bentofamine and I was rather surprised to notice better mobility, better eyesight, less joint pain... then yesterday I took 300 mg, and was able to hold... more
Re: I hope this is real/forever Marilyn Bachmann,Thu Feb 9 20:10
Marilyn - Since reading ur first post about benfot. i have been looking and its not easy to find. Where do u get it? I wud love to give it a try....im in a wheelchair and wud be greatful for anything ... more
I use this company because they ship to Canada using USPS which makes it much much more affordable for me. But they are a great company, I highly recommend them because I have used them for years and ... more
I have read a couple places to take a B. complex with it. B. vitamins tend to work synergistically... although I did read in one article not to take methylcobalamin with it, but I only saw that in... more
Sorry to bother u again Marilyn but u seem to have done quite a bit of research on this. I have been going over some of the info looking for interactions with other B vitamins. I take B-12 daily for... more
I just ordered some B12 patches and the benfotiamine so when I saw what you said about not taking both together I was like.....uh oh. Good to hear that it won't be a problem. Just took my first... more
This stuff was done more for me than anything besides thyroid. Amazing reduction in pain/stiffness/contraction. I am taking 600 mg at the moment, but might experiment with more. Finally finally... more
other treatments and supplements? Do you feel it is a matter of getting all the nutrition we need to repair a system so everything works? For me this is the case. I continue to support my system as... more
Ignore my earlier post Marilyn about where u get it frm. Ur right about expensive. Im in Canada and i did find it at a compounding pharmacy 120 caps for $43.20. How much does it cost u to get it to... more
I am in Canada also and I cannot believe the price of this stuff up here. I answered you below, there are certain restrictions when using iherb.com. You cannot ship over 3 pounds at a time (but they... more
Glad to hear of your success. I just have a couple questions. 1) do you take the 600 mg at one time? 2) are you in a manual or motorized wheelchair? 3) can you stand at all? 4) can you turn over in... more
I've been taking it all at one time in the morning, on an empty stomach. Most of what I've read says that you can go up to 1200 mg without toxicity issues... there seems to be a lot of controversy... more
The thing that I find astounding about this, is that I take all kinds of B. vitamins, and have done so for years. I can't say that I've never noticed much benefit. I have injected every form of B12,... more
Whooo hoooo....I am so glad that this is helping you. I may even see about getting some for myself. I know that I have heard this recommended in the past by someone but just can't seem to remember... more