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NIH finds infectious prion protein in skin of CJD patients
Thu Nov 23, 2017 10:25
2601:2c4:c780:228c:45b3:c928:cc8c:296b

-----Original Message-----
From: Terry Singeltary
To:
Sent: Thu, Nov 23, 2017 10:22 am
Subject: re-NIH scientists and collaborators find infectious prion protein in skin of CJD patients

>>>Although sCJD patient skin contained ~103- to 105-fold lower prion seeding activity than did sCJD patient brain tissue, all 12 mice from two transgenic mouse lines inoculated with sCJD skin homogenates from two sCJD patients succumbed to prion disease within 564 days after inoculation<<<

for something to be 103 to 105 fold lower prion seeding, yet still be 100% fatal in all test subjects, very disturbing...terry

WEDNESDAY, NOVEMBER 22, 2017

NIH scientists and collaborators find infectious prion protein in skin of CJD patients

http://creutzfeldt-jakob-disease.blogspot.com/2017/11/nih-scientists-and-collaborators-find.html

WEDNESDAY, NOVEMBER 22, 2017

Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease

http://creutzfeldt-jakob-disease.blogspot.com/2017/11/prion-seeding-activity-and-infectivity.html

back to reality...

Thursday, November 16, 2017

Texas Natural Meats Recalls Beef Products Due To Possible Specified Risk Materials Contamination

http://specifiedriskmaterial.blogspot.com/2017/11/texas-natural-meats-recalls-beef.html

SATURDAY, NOVEMBER 4, 2017

FDA 589.2000, Section 21 C.F.R. Animal Proteins Prohibited in Ruminant Feed WARNING Letters and FEED MILL VIOLATIONS OBSERVATIONS 2017 to 2006

http://bovineprp.blogspot.com/2017/11/fda-5892000-section-21-cfr-animal.html

FRIDAY, NOVEMBER 3, 2017

BSE MAD COW TSE PRION DISEASE PET FOOD FEED IN COMMERCE INDUSTRY VS TERRY S. SINGELTARY Sr. A REVIEW

''I have a neighbor who is a dairy farmer. He tells me that he knows of several farmers who feed their cattle expired dog food. These farmers are unaware of any dangers posed to their cattle from the pet food contents. For these farmers, the pet food is just another source of protein.''

IN CONFIDENCE

http://madcowfeed.blogspot.com/2017/11/bse-mad-cow-tse-prion-disease-pet-food.html

TUESDAY, SEPTEMBER 12, 2017

CDC Now Recommends Strongly consider having the deer or elk tested for CWD before you eat the meat

http://chronic-wasting-disease.blogspot.com/2017/09/cdc-now-recommends-strongly-consider.html

SATURDAY, JULY 29, 2017

Risk Advisory Opinion: Potential Human Health Risks from Chronic Wasting Disease CFIA, PHAC, HC (HPFB and FNIHB), INAC, Parks Canada, ECCC and AAFC

http://chronic-wasting-disease.blogspot.com/2017/07/risk-advisory-opinion-potential-human.html

http://chronic-wasting-disease.blogspot.com/

THURSDAY, JULY 20, 2017

USDA OIE Alabama Atypical L-type BASE Bovine Spongiform Encephalopathy BSE animal feeds for ruminants rule, 21 CFR 589.200

http://bovineprp.blogspot.com/2017/07/usda-oie-alabama-atypical-l-type-base.html

SUNDAY, JULY 23, 2017

atypical L-type BASE Bovine Amyloidotic Spongiform Encephalopathy BSE TSE PRION

http://bse-atypical.blogspot.com/2017/07/atypical-l-type-base-bovine-amyloidotic.html

SUNDAY, JULY 23, 2017

Experimental Infection of Cattle With a Novel Prion Derived From Atypical H-Type Bovine Spongiform Encephalopathy

http://bse-atypical.blogspot.com/2017/07/experimental-infection-of-cattle-with.html

SPONTANEOUS ATYPICAL BOVINE SPONGIFORM ENCEPHALOPATHY

***Moreover, sporadic disease has never been observed in breeding colonies or primate research laboratories, most notably among hundreds of animals over several decades of study at the National Institutes of Health25, and in nearly twenty older animals continuously housed in our own facility.***

http://www.nature.com/articles/srep11573

MONDAY, OCTOBER 02, 2017

Creutzfeldt Jakob Disease United States of America USA and United Kingdom UK Increasing and Zoonotic Pontential From Different Species

http://creutzfeldt-jakob-disease.blogspot.com/2017/10/creutzfeldt-jakob-disease-united-states.html

THURSDAY, AUGUST 17, 2017

*** Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States revisited 2017 Singeltary et al

http://creutzfeldt-jakob-disease.blogspot.com/2017/08/monitoring-occurrence-of-emerging-forms.html

WEDNESDAY, NOVEMBER 1, 2017

Blood-derived amyloid-β protein induces Alzheimer’s disease pathologies

http://betaamyloidcjd.blogspot.com/2017/11/blood-derived-amyloid-protein-induces.html

MONDAY, NOVEMBER 06, 2017

Experimental transfusion of variant CJD-infected blood reveals previously uncharacterised prion disorder in mice and macaque

''On secondary and tertiary transmissions, however, the proportion of PrPres positive animals gradually increased to almost 100%.

''Recent communications suggest that a similar situation might exist in other models of experimental exposure to prions involving swine32 and cattle33.''

''Experimental transfusion of variant CJD-infected blood reveals previously uncharacterised prion disorder in mice and macaque''

http://vcjd.blogspot.com/2017/11/experimental-transfusion-of-variant-cjd.html

Alzheimer's disease

let's not forget the elephant in the room. curing Alzheimer's would be a great and wonderful thing, but for starters, why not start with the obvious, lets prove the cause or causes, and then start to stop that. think iatrogenic, friendly fire, or the pass it forward mode of transmission. think medical, surgical, dental, tissue, blood, related transmission. think transmissible spongiform encephalopathy aka tse prion disease aka mad cow type disease...

Commentary: Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

http://journals.plos.org/plosone/article/comment?id=info:doi/10.1371/annotation/933cc83a-a384-45c3-b3b2-336882c30f9d

https://www.frontiersin.org/articles/10.3389/fnagi.2016.00005/full

Diagnosis and Reporting of Creutzfeldt-Jakob Disease

Singeltary, Sr et al. JAMA.2001; 285: 733-734. Vol. 285 No. 6, February 14, 2001 JAMA Diagnosis and Reporting of Creutzfeldt-Jakob Disease

To the Editor:

In their Research Letter, Dr Gibbons and colleagues1 reported that the annual US death rate due to Creutzfeldt-Jakob disease (CJD) has been stable since 1985. These estimates, however, are based only on reported cases, and do not include misdiagnosed or preclinical cases. It seems to me that misdiagnosis alone would drastically change these figures. An unknown number of persons with a diagnosis of Alzheimer disease in fact may have CJD, although only a small number of these patients receive the postmortem examination necessary to make this diagnosis. Furthermore, only a few states have made CJD reportable. Human and animal transmissible spongiform encephalopathies should be reportable nationwide and internationally.

Terry S. Singeltary, Sr Bacliff, Tex

1. Gibbons RV, Holman RC, Belay ED, Schonberger LB. Creutzfeldt-Jakob disease in the United States: 1979-1998. JAMA. 2000;284:2322-2323.

http://jama.jamanetwork.com/article.aspx?articleid=1031186



Terry S. Singeltary Sr.
Bacliff, Texas USA 77518
flounder9@verizon.net

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